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James Madison University

 

Research Interests

Courses


Curriculum Vitae

Research Group Website

Chemistry Department

College of Science and Mathematics




 
Dr. Kevin L. Caran

Education

  • Ph.D. Emory University (2001)
              research advisor: Prof. Fredric M. Menger
              dissertation: I. L-Cystine-derived thermoreversible aqueous gelators
                                     II. Morphological and chemical studies on large and giant vesicles
     
  • B.A. Colgate University (1996)
              research advisor: Prof. John C. Cochran
              project: Kinetics of hydrostannation of electron-poor alkynes

Professional Appointments

Publications

Published or in press:

21

LaDow, J. E.; Warnock, D. C.; Hamill, K. M.; Simmons, K. L.; Davis, R. W.; Schwantes, C. R.; Flaherty, D. C.; Willcox, J. A. L.; Wilson-Henjum, K.; Caran, K. L.; Minbiole, K. P. C.; Seifert, K. "Bicephalic Amphiphile Architecture Affects Antibacterial Activity" European Journal of Medicinal Chemistry, 2011, in press. doi:10.1016/j.ejmech.2011.06.026

20

Augustine, B. H.; Caran, K. L.; Reisner, B. A. “An Evolutionary Approach to Nanoscience in the Undergraduate Chemistry Curriculum at James Madison University” Book chapter in Nanotechnology in Undergraduate Education (ACS Symposium Series), K. A. Pacheco, R. Schwenz, W. Jones  ed, American Chemical Society, Washington, D.C., Feb 9, 2010, Oxford University Press; ISBN-10: 0841269688; ISBN-13: 978-0841269682. [link]

19

Roszak, K. Z.; Torcivia, S. L.; Hamill, K. M.; Hill, A. R.; Radloff, K. R.; Crizer, D. M.; Middleton, A. M.; Caran, K. L. “Biscationic Bicephalic (Double-Headed) Amphiphiles with an Aromatic Spacer and a Single Hydrophobic Tail” Journal of Colloid and Interface Science, 2009, 331, 560-564. [link]

18

Borges, A. R.; Hyacinth, M.; Lum, M.; Dingle, C. M.; Hamilton, P. L.; Chruszcz, M.; Pu, L.; Sabat, M.; Caran, K. L. “Self-Assembled Thermoreversible Gels of Non-Polar Liquids by Racemic Propargylic Alcohols with Fluorinated and Non-Fluorinated Aromatic Rings” Langmuir 2008, 24, 7421-7431. [link]

17

Sasine, J. S.; Brewster, R. E.; Caran, K. L.; Shuker, S. B. “Dimerization studies of calix[4]arene derivatives in polar solvents” Org. Lett. 2006, 8, 2913-2915. [link]

16

Brewster, R. E.; Caran, K. L.; Sasine, J. S.; Shuker, S. B.  “Peptidocalixarenes in Molecular Recognition” Curr. Org. Chem. 2004, 8, 867-881. [link]

15

Cochran, J. C.; Caran, K. L.; Pierz, E. A.; Miller, D. A. “Kinetics of the Uncatalyzed Hydrostannation of Diethyl Acetylenedicarboxylate” Syn. React. Inorg. Met. 2003, 33, 725-734. [link]

14

Menger, F. M.; Keiper, J. S.; Caran, K. L. “Depth Profiling with Giant Vessicle Membranes” J. Am. Chem. Soc. 2002, 124, 11842-11843. [pdf]

13

Menger, F. M.; Zhang, H.; Caran, K. L.; Seredyuk, V. A.; Apkarian, R. P. “Gemini-Induced Columnar Jointing in Vitreous Ice.  Cryo-HRSEM as a Tool for Discovering New Colloidal Morphologies” J. Am. Chem. Soc. 2002, 124, 1140-1141.[pdf]

12

Menger, F. M.; Caran, K. L.; Seredyuk, V. A. “Chemical Reactions Between Colliding Vesicles” Angew. Chem. Int. Ed. 2001, 40, 3905-3907.[pdf]

11

Barragan, V.; Menger, F. M.; Caran, K. L.; Vidil, C.; Morère, A.; Montero, J.-L. “A Mannose-6-phosphonate/cholesterylamine Conjugate as a Specific Molecular Adhesive Linking Cancer Cells with Vesicles” Chem. Commun. 2001, 85-86. [pdf]

10

Menger F. M.; Peresypkin, A. V.; Caran, K. L.; Apkarian, R. P. “A Sponge Morphology in an Elementary Coacervate” Langmuir 2000, 16, 9113-9116. [pdf]

9

Menger, F. M.; Caran, K. L. “Anatomy of a Gel. Amino Acid Derivatives that Rigidify Water at Sub-Millimolar Concentrations” J. Am. Chem. Soc. 2000, 122, 11679-11691. [pdf]

8

Menger, F. M.; Keiper, J. S.; Mbadugha, B. N. A.; Caran, K. L.; Romsted, L. S. “Interfacial Composition of Gemini Surfactant Micelles Determined by Chemical Trapping” Langmuir 2000, 16, 9095-9098. [pdf]

7

Apkarian, R. P.; Caran, K. L. “Tandem Cryo-Scanning Transmission and Cryo-High Resolution Secondary Electron Microscopy (SE-I) of Bio-Molecular Complexes” Proc. of Scanning ’00 2000.

6

Menger, F. M.; Caran, K. L.; Apkarian, R. P. “In-lens Cryo-High Resolution Scanning Electron Microscopy (Cryo-HRSEM) of Large Vesicles” Langmuir 2000, 16, 98-101. [pdf]

5

 McMillan, R. A.; Caran, K L.; Apkarian, R. P.; Conticello, V. P. “High Resolution Topographic Imaging of Environmentally Responsive, Elastin-Mimetic Hydrogels” Macromolecules 1999, 32, 9067-9070. [pdf]

4

Apkarian, R. P.; Caran, K. L.; Robinson, K. A. “Topographic Imaging of Chromium-Coated Frozen-Hydrated Cell and Macromolecular Complexes by In-lens Field Emission SEM” Microsc. Microanal. 1999, 5, 197-207 (feature article).

3

Caran, K. L.; Apkarian, R. P.; Menger, F. M. “Examination of Large Unilamellar Vesicles (LUVs) using cryo-HRSEM and cryo-STEM” Proc. 57th Ann. Meeting Microsc. Microanal. 1999, 5, 1210-1211.

2

Wendt, M. C.; Robinson, K. A.; Chronos, N. A. F.; Caran, K. L.; Apkarian, R. P. “Application of Cryo-High Resolution (HR) SEM Technique for Imaging Platelet Morphology” Proc. 57th Ann. Meeting Microsc. Microanal. 1999, 5, 1116-1117.

1

Apkarian, R. P.; Caran, K. L. “Magnetron-Sputtered Chromium Films for In-Lens Field Emission CryoScanning Electron Microscopy” Proc. of Scanning ’98 1998, 20 (3a), 195-196.

Submitted, in revision, or in preparation:

1

Hyacinth, M. A.; Chruszcz, M,; Caran, K. L.; Sabat, M.; Pu, L.; “Racemic Propargylic Alcohols and Their Optically Active Enantiomers: Supramolecular Structure and Hirshfeld Analysis of the Solid State Interactions” submitted to The Journal of Organic Chemistry.

2

Torcivia, S. L.; Caran, K. L. “Synthesis and Colloidal Study of Gemini Surfactants: Modular Nanoscience Experiments Integrated Across the Chemistry Curriculum” in revision.

3

Hamilton, P. L.; Hyacinth, M. A.; Pu, L.; Sabat, M.; Caran K. L. "Isomeric Diaryl Propargylic Alcohol Gelators: Effects of Modifying Stereochemical and Regiochemical Configuration" in preparation.


Presentations (Undergraduate co-authors are italicized)

  • The most recent presentations (including links and photos) of the Caran group can be found by clicking here. KC's presentations prior to coming to JMU (Fall 2003) are below.
     
  • National Organic Symposium, Indianapolis, IN; June 8-12, 2003. Poster Presentation: Caran, K. L.; Sasine, J. S.; Shuker, S. B. “Designing Calix[4]arene Dimers as Molecular Capsules”.

·        Eleventh Annual Suddeth Bioscience Symposium.  Georgia Institute of Technology, Atlanta, GA, March 27-29, 2003. Poster Presentation: Caran, K. L.; Sasine, J. S.; Brewster, R. E.; Shuker, S. B.; “Designing Calix[4]arene Dimers as Molecular Capsules”.

·        225th National Meeting of the American Chemical Society, New Orleans, LA; March 23-27, 2003. Oral Presentation: Caran, K. L.; Reyes, L.-R.; Marek, S.; Shuker, S. B. “Interdigitated and Extended Calix[4]arene Dimers as Molecular Capsules”.

·        Southeast Reginal Meeting of the American Chemical Society (SERMACS), Charleston, SC; November 13-16, 2002. Oral Presentation: Caran, K. L.; Reyes, L.-R.; Shuker, S. B. “Calix[4]arene Dimers as Tunable Molecular Capsules”.

·        224th National Meeting of the American Chemical Society, Boston, MA; August 18-22, 2002.  Poster Presentation: Caran, K. L.; Shuker, S. B. “Calix[4]arenes Substituted on Their Upper Rim with Two Unique Substitutents”.

·        Tenth Annual Suddeth Bioscience Symposium. Georgia Institute of Technology, Atlanta, GA, April, 2002. Poster Presentation: Brewster, R. E.; Sasine, J. S.; Caran, K. L.; Shuker, S. B. "Dimerization of Peptidocalix[4]arenes".

  • 223rd National Meeting of the American Chemical Society, Orlando, FL; April 7-11, 2002.
  • Invited Lecture for U.S. Civilian Research and Development Foundation (CRDF) Grant for the Independent States of the Former Soviet Union, Moscow State University, Moscow, Russia; October 18, 2000. Caran, K. L.; Menger, F. M. "Studies on a New Class of Thermoreversible Gelators based on L-Cystine".
  • 13th International Symposium on Surfactants in Solution (SIS-2000), University of Florida, Gainesville, FL; June 11-16, 2000. Oral presentation: Caran, K. L.; Menger, F. M. "NMR, SEM and Rheological Studies on a Family of Gemini Cystine-Based Gelators".
  • Graduate Research Interdisciplinary Team of Scientists (GRITS) Lecture, Emory University, Atlanta, GA; April 18, 2000. Oral Presentation: Caran, K. L.; Menger, F. M. "Physical Aqueous Gels Composed of L-Cystine".
  • Symposium on Interdisciplinary Research, Emory University, Atlanta, GA; March 31, 2000. Poster Presentation: Caran, K. L.; Menger, F. M. "Non-covalent Bonding Interactions of Thermoreversible Aqueous Gels".
  • 218th National Meeting of the American Chemical Society, New Orleans, LA; August 22-26, 1999. Poster Presentation: Caran, K. L.; Menger, F. M. "Small-Molecule Aqueous Gelators Based on L-Cystine".
  • Microscopy and Microanalysis '98, Atlanta, GA; July 12-16, 1998.
  • Workshop on Giant Vesicles, Monte Verita, Ascona, Switzerland; June 21-25, 1998. Poster presentation: Caran, K. L.; Barragan, V.; Montero, J. L.; Vidil, C.; Morere, A.; Menger, F. M. "Targeting Breast Cancer Cells with Large and Giant Vesicles".
  • National Conference for Undergraduate Research (NCUR), Asheville, NC; Spring, 1996. Poster presentation: Caran, K. L.; Cochran, J. C. "Kinetics and Mechanism of the Uncatalyzed Hydrostannation of Diethylacetylene Dicarboxylate".

Grants Funded:

1.        Research Corporation Cottrell College Science Award “Facile Synthesis and Derivatization of Two Novel Rigid Trimeric Scaffolds” $35,000, Kevin L. Caran (PI), 6/1/04 – 12/31/08 (including no-cost extension).

2.        James Madison University Center for Instructional Technology SEED Grant “Developing Tutorials for Online Chemistry Education” $200, Kevin L. Caran, 8/04. 

3.        American Chemical Society – Petroleum Research Fund “Amphiphilic Catenanes” $35,000, Kevin L. Caran (PI), 9/1/05 - 8/31/09 (including no-cost extension). 

4.        National Science Foundation – Nanotechnology in Undergraduate Education “NUE: An Evolutionary Approach to Nanoscience Education across the Undergraduate Chemistry Curriculum” $190,000, Brian Augistine (PI), Barbara Reisner (co-PI), Kevin Caran (co-PI), 1/1/06 – 8/31/08 (including no-cost extension).  

Professional Affiliations

 

 

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Last Modified: 06/30/2011