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James Madison University

 

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Experience
Associate Professor, James Madison University, August 2009 to present

Assistant Professor, James Madison University, August 2003 to 2009

Visiting Professor, Massachusetts Institute of Technology, Fall 2006 (photo)

Education
B.S.,
University of Notre Dame, 1996
Advisor: Professor Paul Helquist

Ph.D.,
University of Pennsylvania, 2001
Advisor: Professor Amos B. Smith, III.  (photo)
Thesis: The Total Synthesis of Phorboxazole A

Postdoctoral Research, Harvard University, 2001-2003
Advisor: Professor Andrew Myers
American Cancer Society Fellow

Publications (Undergraduate coworkers underlined).
12.  Jade E. LaDow, David C. Warnock, Kristina M. Hamill, Kaitlin L. Simmons, Robert W. Davis, Christian R. Schwantes, Devon C. Flaherty, Kevin L. Caran,  Kevin P. C. Minbiole, and Kyle Seifert. Bicephalic Amphiphile Architecture Affects Antimicrobial Activity.  European Journal of Medicinal Chemistry, in press.

11.  Kevin P. C. Minbiole, Patrick J. Wiggins, Jacob Smith, Reid N. Harris. The Salamander Gut May Serve as a Reservoir for an Antifungal Cutaneous Bacterium.  Journal of Herpetology.  In press.

10. Matthew Becker, Robert Brucker, Reid N. Harris, Christian Schwantes, Kevin P. C. Minbiole. The bacterially-produced metabolite violacein is associated with survival in amphibians infected with a lethal disease. Applied and Environmental Microbiology, 2009, 75, 21, 6635-6638.  (PDF)

9. Reid N. Harris, Robert M. Brucker, Jenifer B. Walke, Matthew H. Becker, Christian R. Schwantes, Devon C. Flaherty, Brianna A. Lam, Doug C. Woodhams, Cheryl J. Briggs, Vance T. Vredenburg, Kevin P. C. Minbiole. Skin microbes on frogs prevent morbidity and mortality caused by a lethal skin fungus,  ISME Journal2009, 3, 818-824.  (PDF)

8. Robert M. Brucker, Reid N. Harris, Christian R. Schwantes, Thomas N. Gallaher, Devon C. Flaherty, Brianna A. Lam, Kevin P. C. Minbiole. Amphibian chemical defense: Antifungal metabolites of the microsymbiont Janthinobacterium lividum on the salamander Plethodon cinereus. J. Chem. Ecol. 2008, 34, 1422-1429. (PDF)

7. Robert M. Brucker, Cambria M. Baylor, Robert L. Walters, Antje Lauer, Reid N. Harris, Kevin P. C. Minbiole. The Identification of 2,4-diacetylphloroglucinol as an Antifungal Metabolite Produced by Cutaneous Bacteria of the Salamander Plethodon cinereus.  J. Chem. Ecol. 2008, 34, 39-43. (PDF)

6. Kerry E. O'Neil, Seth V. Kingree, Kevin P. C. Minbiole.  A Cyclopropane Fragmentation Approach to Heterocycle Assembly:  A Convergent Synthesis of Oxepanes.  Org. Lett., 2005, 7, 515-517. (PDF

5. Amos B. Smith, III; Kevin P. Minbiole; Patrick R. Verhoest; Michael Schelhaas. Total Synthesis of (+)-Phorboxazole A Exploiting the Petasis-Ferrier Rearrangement. J. Am. Chem. Soc. 2001, 123, 10942-10953. (PDF)

4. Amos B. Smith,
III; Kevin P. Minbiole; Scott Freeze. Facile Assembly of 2,4-Orthogonally-Functionalized Oxazoles: Useful Bidirectional Linchpins. Synlett 2001, 13, 1739-1742. (PDF)

3. Amos B. Smith,
III; Patrick R. Verhoest; Kevin P. Minbiole; Michael Schelhaas. Total Synthesis of (+)-Phorboxazole A. J. Am. Chem. Soc. 2001, 123, 4834-4836. (PDF)

2. Amos B. Smith,
III; Kevin P. Minbiole; Patrick R. Verhoest; Thomas J. Beauchamp. Phorboxazole Synthetic Studies. 2. Construction of a C(20-28) Subtarget, a Further Extension of the Petasis-Ferrier Rearrangement. Org. Lett. 1999, 1, 913-916. (PDF)

1. Amos B. Smith,
III; Patrick R. Verhoest; Kevin P. Minbiole; John J. Lim. Phorboxazole Synthetic Studies. 1. Construction of a C(3-19) Subtarget Exploiting an Extension of the Petasis-Ferrier Rearrangement. Org. Lett. 1999, 1, 909-912. (PDF)
 

Book Chapter
Minbiole, K. P. C. “Product Class 46.4: 1,3 Dienes; Synthesis by Aldol and Related Condensations.” In Science of Synthesis; Volume 46; Rawal, V. H. and Kozmin, S. A., Volume Editors. Georg Thieme Verlag: Stuttgart, September 2009.


Mini-review
Harris, R. N.; Minbiole, K. P. C.  "Can Manipulations of Amphibians’ Mutualistic Skin Bacteria Control a Lethal Skin Disease?"  Biocontrol News and Information 2009, 30 (2), 19N–20N. (PDF)


Patents
US Provisional Patent Application; "Antimicrobial Amphiphiles and Methods for their Use."  Submitted October 2010

US Patent Application 12/829,520 and International Patent Application US10/40898;  "Probiotic Compositions and Processes Thereof."  July 2010


Presentations (Before JMU)
Paul Helquist, Kevin P. Minbiole. "Synthetic Derivatization and Biological Degradation of Virginiamycin M1." Student Poster Session,
ACS South Bend Chapter, University of Notre Dame, April 1996.

Amos B. Smith,
III, Kevin P. Minbiole, Patrick R. Verhoest, and Michael Schelhaas. "The Total Synthesis of Phorboxazole A" 37th National Organic Symposium, Montana State University, June 2002.

 

 

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Last Modified: 09/13/2011