Our Research

Increasingly, chemistry is having an impact in other fields, such as materials science and biology. Our research program focuses on exploiting organic and organometallic chemistry to solve problems in these fields.

The primary focus of our research involves using photoactivatable sources of organic radicals to modify biomolecules to achieve the following goals:

In each of these areas, organic radicals generated from CpMLnR complexes are ideal for a number of reasons: their production is triggerable, tunable, and can be targeted; and the complexes are stable, readily available, and easily functionalized with biomolecular recognition elements. Furthermore, the use of light activation provides spatiotemporal control, which will be vital to eventual applications in vivo. The stoichiometic control provided by the photochemical generation of the radical species from the metal complex allows regulation over the number of biomolecular radicals formed, increasing the yield of the desired modified biomolecules.

In addition, a few students in the group are working in the following areas:

These areas represent our fascination with the interactions of "small" and "big" molecules (and the resulting effects, including biological activity) and with the development of new "big" molecules with interesting properties.